The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration

The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration

Abstract Background Myelin sheath is a crucial accessory to the functional nerve-fiber unit, its disruption or loss can lead to axonal degeneration and subsequent neurodegenerative diseases (NDs). Notwithstanding of substantial progress in possible molecular mechanisms underlying myelination, there...

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Bibliographic Details
Main Authors: Jinghui Xu, Bin Zhang, Jieyi Cai, Qianqian Peng, Junxia Hu, Parizat Askar, Jianghong Shangguan, Wenfeng Su, Changlai Zhu, Hualin Sun, Songlin Zhou, Gang Chen, Xiaoming Yang, Yun Gu
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Molecular Medicine
Subjects:
Stat1
Schwann cells
Differentiation
Myelination and remyelination
Demyelinating diseases
Online Access:https://doi.org/10.1186/s10020-023-00667-w

Internet

https://doi.org/10.1186/s10020-023-00667-w

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