The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration

The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration

Abstract Background Myelin sheath is a crucial accessory to the functional nerve-fiber unit, its disruption or loss can lead to axonal degeneration and subsequent neurodegenerative diseases (NDs). Notwithstanding of substantial progress in possible molecular mechanisms underlying myelination, there...

Full description

Bibliographic Details
Main Authors: Jinghui Xu, Bin Zhang, Jieyi Cai, Qianqian Peng, Junxia Hu, Parizat Askar, Jianghong Shangguan, Wenfeng Su, Changlai Zhu, Hualin Sun, Songlin Zhou, Gang Chen, Xiaoming Yang, Yun Gu
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Molecular Medicine
Subjects:
Stat1
Schwann cells
Differentiation
Myelination and remyelination
Demyelinating diseases
Online Access:https://doi.org/10.1186/s10020-023-00667-w

Similar Items

Similar Items