PHACTR1, a coronary artery disease risk gene, mediates endothelial dysfunction

PHACTR1, a coronary artery disease risk gene, mediates endothelial dysfunction

Genome-wide association studies (GWAS) have recently identified phosphatase and actin regulator-1 (PHACTR1) as a critical risk gene associated with polyvascular diseases. However, it remains largely unclear how PHACTR1 is involved in endothelial dysfunction. Here, by mining published datasets of hum...

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Bibliographic Details
Main Authors: Xiaoxuan Ma, Meiming Su, Qingze He, Zhidan Zhang, Fanshun Zhang, Zhenghong Liu, Lu Sun, Jianping Weng, Suowen Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
endothelial dysfunction
inflammation
PHACTR1
cardiovascular disease
RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.958677/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.958677/full

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