Negative regulation of type I interferon signaling by integrin-linked kinase permits dengue virus replication.

Dengue virus (DENV) infection can induce life-threatening dengue hemorrhagic fever/dengue shock syndrome in infected patients. DENV is a threat to global health due to its growing numbers and incidence of infection in the last 50 years. During infection, DENV expresses ten structural and nonstructur...

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Main Authors: Yi-Sheng Kao, Li-Chiu Wang, Po-Chun Chang, Heng-Ming Lin, Yee-Shin Lin, Chia-Yi Yu, Chien-Chin Chen, Chiou-Feng Lin, Trai-Ming Yeh, Shu-Wen Wan, Jen-Ren Wang, Tzong-Shiann Ho, Chien-Chou Chu, Bo-Cheng Zhang, Chih-Peng Chang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011241