Development of [89Zr]Zr-hCD103.Fab01A and [68Ga]Ga-hCD103.Fab01A for PET imaging to noninvasively assess cancer reactive T cell infiltration: Fab-based CD103 immunoPET

Development of [89Zr]Zr-hCD103.Fab01A and [68Ga]Ga-hCD103.Fab01A for PET imaging to noninvasively assess cancer reactive T cell infiltration: Fab-based CD103 immunoPET

Abstract Background CD103 is an integrin specifically expressed on the surface of cancer-reactive T cells. The number of CD103+ T cells significantly increases during successful immunotherapy and might therefore be an attractive biomarker for noninvasive PET imaging of immunotherapy response. Since...

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Bibliographic Details
Main Authors: Xiaoyu Fan, Marta A. Ważyńska, Arjan Kol, Noemi Perujo Holland, Bruna Fernandes, Sander M. J. van Duijnhoven, Annechien Plat, Hans van Eenennaam, Philip H. Elsinga, Hans W. Nijman, Marco de Bruyn
Format: Article
Language:English
Published: SpringerOpen 2023-11-01
Series:EJNMMI Research
Subjects:
CD103
Biomarker
ImmunoPET
89Zr
68Ga
Online Access:https://doi.org/10.1186/s13550-023-01043-9

Internet

https://doi.org/10.1186/s13550-023-01043-9

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