RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated β-catenin suppression

RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated β-catenin suppression

Abstract Ribosome biogenesis (RiBi) plays a pivotal role in carcinogenesis by regulating protein translation and stress response. Here, we find that RRP15, a nucleolar protein critical for RiBi and checkpoint control, is frequently upregulated in primary CRCs and higher RRP15 expression positively c...

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Bibliographic Details
Main Authors: Zhixiong Dong, Jinhai Li, Wenqing Dai, Dongbo Yu, Youjuan Zhao, Shuanghui Liu, Xuanwen Li, Zhengzheng Zhang, Rui Zhang, Xue Liang, Qingran Kong, Shengnan Jin, Hao Jiang, Wei Jiang, Chunming Ding
Format: Article
Language:English
Published: Nature Publishing Group 2023-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05578-6

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https://doi.org/10.1038/s41419-023-05578-6

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