Temporal changes in cyclinD-CDK4/CDK6 and cyclinE-CDK2 pathways: implications for the mechanism of deficient decidualization in an immune-based mouse model of unexplained recurrent spontaneous abortion

Temporal changes in cyclinD-CDK4/CDK6 and cyclinE-CDK2 pathways: implications for the mechanism of deficient decidualization in an immune-based mouse model of unexplained recurrent spontaneous abortion

Abstract Background Deficient endometrial decidualization has been associated with URSA. However, the underlying mechanism is poorly understood. This study aimed to investigate the temporal cytokine changes and the involvement of CyclinD-CDK4/6 and CyclinE-CDK2 pathways in the regulation of the G1 p...

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Bibliographic Details
Main Authors: Zhuo Chang, Hai-xue Kuang, Xueming Zhou, Hui Zhu, Yang Zhang, Yin Fu, Qiang Fu, Bei Jiang, Wei Wang, Sha Jiang, Li Ren, Lei Ma, Xue Pan, Xiao-ling Feng
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Molecular Medicine
Subjects:
Unexplained recurrent spontaneous abortion
Decidualization
Cell cycle
Online Access:https://doi.org/10.1186/s10020-022-00523-3

Internet

https://doi.org/10.1186/s10020-022-00523-3

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