shRNAs targeting mouse Adam10 diminish cell response to proinflammatory stimuli independently of Adam10 silencing

shRNAs targeting mouse Adam10 diminish cell response to proinflammatory stimuli independently of Adam10 silencing

RNA interference is one of the common methods of studying protein functions. In recent years critical reports have emerged indicating that off-target effects may have a much greater impact on RNAi-based analysis than previously assumed. We studied the influence of Adam10 and Adam17 silencing on MC38...

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Bibliographic Details
Main Authors: Maria Czarnek, Krystyna Stalińska, Katarzyna Sarad, Joanna Bereta
Format: Article
Language:English
Published: The Company of Biologists 2022-03-01
Series:Biology Open
Subjects:
rna interference
shrna
off-target effects
adam10
adam17
Online Access:http://bio.biologists.org/content/11/3/bio059092

Internet

http://bio.biologists.org/content/11/3/bio059092

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