Favorable Effects of Voriconazole Trough Concentrations Exceeding 1 μg/mL on Treatment Success and All-Cause Mortality: A Systematic Review and Meta-Analysis

Favorable Effects of Voriconazole Trough Concentrations Exceeding 1 μg/mL on Treatment Success and All-Cause Mortality: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis examined the optimal trough concentration of voriconazole for adult patients with invasive fungal infections. We used stepwise cutoffs of 0.5–2.0 μg/mL for efficacy and 3.0–6.0 μg/mL for safety. Studies were included if they reported the rates of all-cause mo...

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Bibliographic Details
Main Authors: Yuki Hanai, Yukihiro Hamada, Toshimi Kimura, Kazuaki Matsumoto, Yoshiko Takahashi, Satoshi Fujii, Kenji Nishizawa, Yoshitsugu Miyazaki, Yoshio Takesue
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Journal of Fungi
Subjects:
voriconazole
meta-analysis
trough concentration
therapeutic drug monitoring
mortality
Online Access:https://www.mdpi.com/2309-608X/7/4/306

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https://www.mdpi.com/2309-608X/7/4/306

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