Cartilage-specific knockout of miRNA-128a expression normalizes the expression of circadian clock genes (CCGs) and mitigates the severity of osteoarthritis

Cartilage-specific knockout of miRNA-128a expression normalizes the expression of circadian clock genes (CCGs) and mitigates the severity of osteoarthritis

Background: Micro-ribonucleic acids (miRNAs) are involved in osteoarthritis (OA) pathogenesis and clock-controlled genes (CCGs) regulation. However, the interaction between miRNAs and CCGs remains unclear. Methods: Human OA samples were used to assess CCGs expression. Cartilage-specific miR-128a kno...

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Bibliographic Details
Main Authors: Jih-Yang Ko, Feng-Sheng Wang, Wei-Shiung Lian, Hsiao-Chi Fang, Shu-Jui Kuo
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Biomedical Journal
Subjects:
Osteoarthritis
miRNA-128a
NR1D2 (nuclear receptor subfamily 1 group D member 2)
Online Access:http://www.sciencedirect.com/science/article/pii/S2319417023000665

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http://www.sciencedirect.com/science/article/pii/S2319417023000665

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