K+‐independent Kir blockade by external Cs+ and Ba2+

Abstract Cations such as Cs+ and Ba2+ are known to block K+ currents by entering an open channel and binding to the selectivity filter, where they obstruct the pore and block diffusion of the permeant ion. This obstruction is voltage‐ and K+‐dependent and is relieved by the trans permeant ion flux....

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Bibliographic Details
Main Author: Gilles Ouanounou
Format: Article
Language:English
Published: Wiley 2022-03-01
Series:Physiological Reports
Subjects:
Online Access:https://doi.org/10.14814/phy2.15200