Mucociliary Wnt signaling promotes cilia biogenesis and beating

Motile cilia are thought of as signaling-inert nanomotors. Here, the authors show that motile cilia transduce a Wnt-protein phosphatase 1 signal that regulates cilia biogenesis and ciliary beating in Xenopus embryos and in human airway epithelia.

Bibliographic Details
Main Authors: Carina Seidl, Fabio Da Silva, Kaiqing Zhang, Kai Wohlgemuth, Heymut Omran, Christof Niehrs
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36743-2