LFA-1 nanoclusters integrate TCR stimulation strength to tune T-cell cytotoxic activity

LFA-1 nanoclusters integrate TCR stimulation strength to tune T-cell cytotoxic activity

Abstract T-cell cytotoxic function relies on the cooperation between the highly specific but poorly adhesive T-cell receptor (TCR) and the integrin LFA-1. How LFA-1-mediated adhesion may scale with TCR stimulation strength is ill-defined. Here, we show that LFA-1 conformation activation scales with...

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Bibliographic Details
Main Authors: Claire Lacouture, Beatriz Chaves, Delphine Guipouy, Raïssa Houmadi, Valérie Duplan-Eche, Sophie Allart, Nicolas Destainville, Loïc Dupré
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-44688-3

Internet

https://doi.org/10.1038/s41467-024-44688-3

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