The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation

The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation

Many cellular processes are regulated by ubiquitin-mediated proteasomal degradation. Pathogens can regulate eukaryotic proteolysis through the delivery of proteins with de-ubiquitinating (DUB) activities. The obligate intracellular pathogen Chlamydia trachomatis secretes Cdu1 (ChlaDUB1), a dual deub...

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Bibliographic Details
Main Authors: Robert J Bastidas, Mateusz Kędzior, Robert K Davidson, Stephen C Walsh, Lee Dolat, Barbara S Sixt, Jonathan N Pruneda, Jörn Coers, Raphael H Valdivia
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-02-01
Series:eLife
Subjects:
Chlamydia trachomatis
acetylase
deubiquitinase
bacterial host exit
ubiquitin
bacterial effectors
Online Access:https://elifesciences.org/articles/87386

Internet

https://elifesciences.org/articles/87386

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