Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in Dystrophic Muscles

Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in Dystrophic Muscles

Summary: Fibrosis and fat replacement in skeletal muscle are major complications that lead to a loss of mobility in chronic muscle disorders, such as muscular dystrophy. However, the in vivo properties of adipogenic stem and precursor cells remain unclear, mainly due to the high cell heterogeneity i...

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Bibliographic Details
Main Authors: Jordi Camps, Natacha Breuls, Alejandro Sifrim, Nefele Giarratana, Marlies Corvelyn, Laura Danti, Hanne Grosemans, Sebastiaan Vanuytven, Irina Thiry, Marzia Belicchi, Mirella Meregalli, Khrystyna Platko, Melissa E. MacDonald, Richard C. Austin, Rik Gijsbers, Giulio Cossu, Yvan Torrente, Thierry Voet, Maurilio Sampaolesi
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
single-cell transcriptomics
skeletal muscle
muscular dystrophy
interstitial stromal cells
adipogenesis
GDF10
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720305465

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http://www.sciencedirect.com/science/article/pii/S2211124720305465

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