The cholinergic anti-inflammatory pathway inhibits inflammation without lymphocyte relay

The cholinergic anti-inflammatory pathway inhibits inflammation without lymphocyte relay

The magnitude of innate inflammatory immune responses is dependent on interactions between peripheral neural and immune cells. In particular, a cholinergic anti-inflammatory pathway (CAP) has been identified in the spleen whereby noradrenaline (NA) released by splenic nerves binds to ß2-adrenergic r...

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Bibliographic Details
Main Authors: Thomas Simon, Joseph Kirk, Nikola Dolezalova, Mélanie Guyot, Clara Panzolini, Alexandre Bondue, Julien Lavergne, Sandrine Hugues, Nicolas Hypolite, Kourosh Saeb-Parsy, Justin Perkins, Eric Macia, Arun Sridhar, Margriet J. Vervoordeldonk, Nicolas Glaichenhaus, Matteo Donegá, Philippe Blancou
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Neuroscience
Subjects:
splenic nerve stimulation
cholinergic anti-inflammatory pathway
CD4+ T lymphocytes
myeloid cells
beta2 adrenergic receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1125492/full

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https://www.frontiersin.org/articles/10.3389/fnins.2023.1125492/full

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