XIAP deletion sensitizes mice to TNF-induced and RIP1-mediated death

XIAP deletion sensitizes mice to TNF-induced and RIP1-mediated death

Abstract XIAP is a caspase-inhibitory protein that blocks several cell death pathways, and mediates proper activation of inflammatory NOD2-RIP2 signaling. XIAP deficiency in patients with inflammatory diseases such as Crohn’s disease, or those needing allogeneic hematopoietic cell transplantation, i...

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Bibliographic Details
Main Authors: Axel Witt, Tatiana Goncharov, Yujung Michelle Lee, Matthias Kist, Monika Dohse, Jeff Eastham, Debra Dugger, Kim Newton, Joshua D. Webster, Domagoj Vucic
Format: Article
Language:English
Published: Nature Publishing Group 2023-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05793-1

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https://doi.org/10.1038/s41419-023-05793-1

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