The Prostaglandin E2 Receptor EP4 Promotes Vascular Neointimal Hyperplasia through Translational Control of Tenascin C via the cAMP/PKA/mTORC1/rpS6 Pathway

The Prostaglandin E2 Receptor EP4 Promotes Vascular Neointimal Hyperplasia through Translational Control of Tenascin C via the cAMP/PKA/mTORC1/rpS6 Pathway

Prostaglandin E2 (PGE2) is an important metabolite of arachidonic acid which plays a crucial role in vascular physiology and pathophysiology via its four receptors (EP1-4). However, the role of vascular smooth muscle cell (VSMC) EP4 in neointimal hyperplasia is largely unknown. Here we showed that V...

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Bibliographic Details
Main Authors: Hu Xu, Bingying Fang, Chengzhen Bao, Xiuhui Mao, Chunhua Zhu, Lan Ye, Qian Liu, Yaqing Li, Chunxiu Du, Hang Qi, Xiaoyan Zhang, Youfei Guan
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
vascular stenosis
prostanoid
tenascin C
EP4
gene knockout
Online Access:https://www.mdpi.com/2073-4409/11/17/2720

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https://www.mdpi.com/2073-4409/11/17/2720

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