Mechano-growth factor E-domain modulates cardiac contractile function through 14-3-3 protein interactomes

Mechano-growth factor E-domain modulates cardiac contractile function through 14-3-3 protein interactomes

In the heart, alternative splicing of the igf-I gene produces two isoforms: IGF-IEa and IGF-IEc, (Mechano-growth factor, MGF). The sequence divergence between their E-domain regions suggests differential isoform function. To define the biological actions of MGF’s E-domain, we performed in silico ana...

Full description

Bibliographic Details
Main Authors: Christopher Solís, Walter C. Thompson, James R. Peña, Christopher McDermott-Roe, Paulina Langa, Chad M. Warren, Magdalena Chrzanowska, Beata M. Wolska, R. John Solaro, Pieter Detombe, Paul H. Goldspink
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Physiology
Subjects:
mechano-growth factor
E-domain peptide
14-3-3 protein
contractile function of the heart
protein-protein interaction (PPI)
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.1028345/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.1028345/full

Similar Items