An mRNA vaccine encoding the SARS-CoV-2 receptor-binding domain protects mice from various Omicron variants

An mRNA vaccine encoding the SARS-CoV-2 receptor-binding domain protects mice from various Omicron variants

Abstract Here, we assessed the efficacy of a lipid nanoparticle-based mRNA vaccine candidate encoding the receptor-binding domain (LNP-mRNA-RBD) in mice. Mice immunized with LNP-mRNA-RBD based on the ancestral strain (ancestral-type LNP-mRNA-RBD) showed similar cellular responses against the ancestr...

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Bibliographic Details
Main Authors: Ryuta Uraki, Masaki Imai, Mutsumi Ito, Seiya Yamayoshi, Maki Kiso, Nao Jounai, Kazuki Miyaji, Kiyoko Iwatsuki-Horimoto, Fumihiko Takeshita, Yoshihiro Kawaoka
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-023-00800-0

Internet

https://doi.org/10.1038/s41541-023-00800-0

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