White matter injury, cholesterol dysmetabolism, and APP/Abeta dysmetabolism interact to produce Alzheimer’s disease (AD) neuropathology: A hypothesis and review

White matter injury, cholesterol dysmetabolism, and APP/Abeta dysmetabolism interact to produce Alzheimer’s disease (AD) neuropathology: A hypothesis and review

We postulate that myelin injury contributes to cholesterol release from myelin and cholesterol dysmetabolism which contributes to Abeta dysmetabolism, and combined with genetic and AD risk factors, leads to increased Abeta and amyloid plaques. Increased Abeta damages myelin to form a vicious injury...

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Bibliographic Details
Main Authors: Frank R. Sharp, Charles S. DeCarli, Lee-Way Jin, Xinhua Zhan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
white matter
myelin
cholesterol
APOE
Abeta
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1096206/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1096206/full

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