Intranasal delivery of phenytoin loaded layered double hydroxide nanoparticles improves therapeutic effect on epileptic seizures

Intranasal delivery of phenytoin loaded layered double hydroxide nanoparticles improves therapeutic effect on epileptic seizures

Abstract Improving the efficiency of antiseizure medication entering the brain is the key to reducing its peripheral toxicity. A combination of intranasal administration and nanomedicine presents a practical approach for treating epileptic seizures via bypassing the blood-brain barrier. In this stud...

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Bibliographic Details
Main Authors: Jingxin Zhang, Huali Zuo, Yanlu Fu, Yina Cao, Qiwei Li, Qi Zhang, Yuyi Zheng, Yi Wang, Di Wu, Weiyu Chen, Jiajia Fang
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Nanobiotechnology
Subjects:
Epilepsy
Phenytoin
Intranasal delivery
Layered double hydroxide nanoparticles
Online Access:https://doi.org/10.1186/s12951-024-02405-8

Internet

https://doi.org/10.1186/s12951-024-02405-8

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