Regional vulnerability in Huntington's disease: fMRI-guided molecular analysis in patients and a mouse model of disease

Regional vulnerability in Huntington's disease: fMRI-guided molecular analysis in patients and a mouse model of disease

Although the huntingtin gene is expressed in brain throughout life, phenotypically Huntington's disease (HD) begins only in midlife and affects specific brain regions. Here, to investigate regional vulnerability in the disease, we used functional magnetic resonance imaging (fMRI) to translation...

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Bibliographic Details
Main Authors: Nicole M. Lewandowski, Yvette Bordelon, Adam M. Brickman, Sergio Angulo, Usman Khan, Jordan Muraskin, Erica Y. Griffith, Paula Wasserman, Liliana Menalled, Jean Paul Vonsattel, Karen Marder, Scott A. Small, Herman Moreno
Format: Article
Language:English
Published: Elsevier 2013-04-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
YAC128
PPP1R7
WIF-1
CBV
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112003774

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http://www.sciencedirect.com/science/article/pii/S0969996112003774

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