Convergent epigenetic evolution drives relapse in acute myeloid leukemia

Convergent epigenetic evolution drives relapse in acute myeloid leukemia

Relapse of acute myeloid leukemia (AML) is highly aggressive and often treatment refractory. We analyzed previously published AML relapse cohorts and found that 40% of relapses occur without changes in driver mutations, suggesting that non-genetic mechanisms drive relapse in a large proportion of ca...

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Bibliographic Details
Main Authors: Kevin Nuno, Armon Azizi, Thomas Koehnke, Caleb Lareau, Asiri Ediriwickrema, M Ryan Corces, Ansuman T Satpathy, Ravindra Majeti
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-04-01
Series:eLife
Subjects:
acute myeloid leukemia
relapse
epigenetics
Online Access:https://elifesciences.org/articles/93019

Internet

https://elifesciences.org/articles/93019

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