Substrate-Induced Dimerization of Engineered Monomeric Variants of Triosephosphate Isomerase from Trichomonas vaginalis.

Substrate-Induced Dimerization of Engineered Monomeric Variants of Triosephosphate Isomerase from Trichomonas vaginalis.

The dimeric nature of triosephosphate isomerases (TIMs) is maintained by an extensive surface area interface of more than 1600 Å2. TIMs from Trichomonas vaginalis (TvTIM) are held in their dimeric state by two mechanisms: a ball and socket interaction of residue 45 of one subunit that fits into the...

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Bibliographic Details
Main Authors: Samuel Lara-Gonzalez, Priscilla Estrella, Carmen Portillo, María E Cruces, Pedro Jimenez-Sandoval, Juliana Fattori, Ana C Migliorini-Figueira, Marisol Lopez-Hidalgo, Corina Diaz-Quezada, Margarita Lopez-Castillo, Carlos H Trasviña-Arenas, Eugenia Sanchez-Sandoval, Armando Gómez-Puyou, Jaime Ortega-Lopez, Rossana Arroyo, Claudia G Benítez-Cardoza, Luis G Brieba
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4664265?pdf=render

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http://europepmc.org/articles/PMC4664265?pdf=render

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