TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion

TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion

ERBB2 overexpression in human breast cancer leads to invasion and metastasis. Here the authors report that ERBB2 induces indirect phosphorylation of TOM1L1 that promotes trafficking of the metalloprotease MT1-MMP to invadopodia, which leads to tumour cell invasion.

Bibliographic Details
Main Authors: Clément Chevalier, Guillaume Collin, Simon Descamps, Heiani Touaitahuata, Valérie Simon, Nicolas Reymond, Laurent Fernandez, Pierre-Emmanuel Milhiet, Virginie Georget, Serge Urbach, Laurence Lasorsa, Béatrice Orsetti, Florence Boissière-Michot, Evelyne Lopez-Crapez, Charles Theillet, Serge Roche, Christine Benistant
Format: Article
Language:English
Published: Nature Portfolio 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10765

Internet

https://doi.org/10.1038/ncomms10765

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