Desipramine enhances the stability of atherosclerotic plaque in rabbits monitored with molecular imaging.

Desipramine enhances the stability of atherosclerotic plaque in rabbits monitored with molecular imaging.

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Acid sphingomyelinase (ASM) promotes atherogenesis and acute cardiovascular events. We previously demonstrated ASM inhibitor desipramine attenuated oxidized-LDL-induced macrophage apoptosis in vitro. Here, we aim to determine whether ASM-mediated apoptosis in plaque improves stability in vivo. In th...

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Bibliographic Details
Main Authors: Min Zhao, Baiyang You, Xiaole Wang, Jin Huang, Ming Zhou, Ruizheng Shi, Guogang Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0283612

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https://doi.org/10.1371/journal.pone.0283612

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