LC–MS-based metabolomics in profiling of drug metabolism and bioactivation

LC–MS-based metabolomics in profiling of drug metabolism and bioactivation

Since metabolism significantly affects drug safety and efficacy, determining the metabolic profile of a drug is a critical part of drug development. The application of an LC–MS-based metabolomic approach has gained more widespread use in identifying drug metabolites, developing metabolic maps and le...

Full description

Bibliographic Details
Main Authors: Feng Li, Frank J. Gonzalez, Xiaochao Ma
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Metabolomics
Drug metabolism
Reactive metabolites
Multivariate data analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383512000330

Internet

http://www.sciencedirect.com/science/article/pii/S2211383512000330

Similar Items