LC–MS-based metabolomics in profiling of drug metabolism and bioactivation
Since metabolism significantly affects drug safety and efficacy, determining the metabolic profile of a drug is a critical part of drug development. The application of an LC–MS-based metabolomic approach has gained more widespread use in identifying drug metabolites, developing metabolic maps and le...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2012-04-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383512000330 |
| _version_ | 1818507210713464832 |
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| author | Feng Li Frank J. Gonzalez Xiaochao Ma |
| author_facet | Feng Li Frank J. Gonzalez Xiaochao Ma |
| author_sort | Feng Li |
| collection | DOAJ |
| description | Since metabolism significantly affects drug safety and efficacy, determining the metabolic profile of a drug is a critical part of drug development. The application of an LC–MS-based metabolomic approach has gained more widespread use in identifying drug metabolites, developing metabolic maps and lending clues to mechanisms of bioactivation. Thus, the LC–MS-based metabolomic approach is a powerful tool for profiling of drug metabolism and bioactivation. |
| first_indexed | 2024-12-10T22:15:24Z |
| format | Article |
| id | doaj.art-428fd72a5ad5470eb02810c9df1f120d |
| institution | Directory Open Access Journal |
| issn | 2211-3835 2211-3843 |
| language | English |
| last_indexed | 2024-12-10T22:15:24Z |
| publishDate | 2012-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-428fd72a5ad5470eb02810c9df1f120d2022-12-22T01:31:29ZengElsevierActa Pharmaceutica Sinica B2211-38352211-38432012-04-012211812510.1016/j.apsb.2012.02.010LC–MS-based metabolomics in profiling of drug metabolism and bioactivationFeng Li0Frank J. Gonzalez1Xiaochao Ma2Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USALaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USADepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USASince metabolism significantly affects drug safety and efficacy, determining the metabolic profile of a drug is a critical part of drug development. The application of an LC–MS-based metabolomic approach has gained more widespread use in identifying drug metabolites, developing metabolic maps and lending clues to mechanisms of bioactivation. Thus, the LC–MS-based metabolomic approach is a powerful tool for profiling of drug metabolism and bioactivation.http://www.sciencedirect.com/science/article/pii/S2211383512000330MetabolomicsDrug metabolismReactive metabolitesMultivariate data analysis |
| spellingShingle | Feng Li Frank J. Gonzalez Xiaochao Ma LC–MS-based metabolomics in profiling of drug metabolism and bioactivation Acta Pharmaceutica Sinica B Metabolomics Drug metabolism Reactive metabolites Multivariate data analysis |
| title | LC–MS-based metabolomics in profiling of drug metabolism and bioactivation |
| title_full | LC–MS-based metabolomics in profiling of drug metabolism and bioactivation |
| title_fullStr | LC–MS-based metabolomics in profiling of drug metabolism and bioactivation |
| title_full_unstemmed | LC–MS-based metabolomics in profiling of drug metabolism and bioactivation |
| title_short | LC–MS-based metabolomics in profiling of drug metabolism and bioactivation |
| title_sort | lc ms based metabolomics in profiling of drug metabolism and bioactivation |
| topic | Metabolomics Drug metabolism Reactive metabolites Multivariate data analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2211383512000330 |
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