Expression-based species deconvolution and realignment removes misalignment error in multispecies single-cell data

Expression-based species deconvolution and realignment removes misalignment error in multispecies single-cell data

Abstract Background Although single-cell RNA sequencing of xenograft samples has been widely used, no comprehensive bioinformatics pipeline is available for human and mouse mixed single-cell analyses. Considering the numerous homologous genes across the human and mouse genomes, misalignment errors s...

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Bibliographic Details
Main Authors: Jaeyong Choi, Woochan Lee, Jung-Ki Yoon, Sun Mi Choi, Chang-Hoon Lee, Hyeong-Gon Moon, Sukki Cho, Jin-Haeng Chung, Han-Kwang Yang, Jong-Il Kim
Format: Article
Language:English
Published: BMC 2022-05-01
Series:BMC Bioinformatics
Subjects:
Single-cell sequencing
Patient-derived xenograft
Bioinformatics pipeline
Online Access:https://doi.org/10.1186/s12859-022-04676-0

Internet

https://doi.org/10.1186/s12859-022-04676-0

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