Taste-Masked Flucloxacillin Powder Part 2: Formulation Optimisation Using the Mixture Design Approach and Storage Stability

Taste-Masked Flucloxacillin Powder Part 2: Formulation Optimisation Using the Mixture Design Approach and Storage Stability

Flucloxacillin is prescribed to treat skin infections but its highly bitter taste is poorly tolerated in children. This work describes the application of the D-optimal mixture experimental design to identify the optimal component ratio of flucloxacillin, Eudragit EPO and palmitic acid to prepare flu...

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Bibliographic Details
Main Authors: Okhee Yoo, Sam Salman, Britta S. von Ungern-Sternberg, Lee Yong Lim
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceuticals
Subjects:
flucloxacillin
Eudragit EPO
palmitic acid
taste-masked microparticles
mixture design
paediatric formulation
Online Access:https://www.mdpi.com/1424-8247/16/8/1179

Internet

https://www.mdpi.com/1424-8247/16/8/1179

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