Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy

Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy

Abstract Translation of upstream open reading frames (uORFs) typically abrogates translation of main (m)ORFs. The molecular mechanism of uORF regulation in cells is not well understood. Here, we data-mined human and mouse heart ribosome profiling analyses and identified a double-stranded RNA (dsRNA)...

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Bibliographic Details
Main Authors: Omar M. Hedaya, Kadiam C. Venkata Subbaiah, Feng Jiang, Li Huitong Xie, Jiangbin Wu, Eng-Soon Khor, Mingyi Zhu, David H. Mathews, Chris Proschel, Peng Yao
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41799-1

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https://doi.org/10.1038/s41467-023-41799-1

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