Properties of rabies virus phosphoprotein and nucleoprotein biocondensates formed in vitro and in cellulo.

Rabies virus (RABV) transcription and replication take place within viral factories having liquid properties, called Negri bodies (NBs), that are formed by liquid-liquid phase separation (LLPS). The co-expression of RABV nucleoprotein (N) and phosphoprotein (P) in mammalian cells is sufficient to in...

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Main Authors: Quentin Nevers, Nathalie Scrima, Damien Glon, Romain Le Bars, Alice Decombe, Nathalie Garnier, Malika Ouldali, Cécile Lagaudrière-Gesbert, Danielle Blondel, Aurélie Albertini, Yves Gaudin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011022