Tandem mass tag-based proteomic profiling revealed potential therapeutic targets and mechanisms of liraglutide for the treatment of impaired glucose tolerance

Tandem mass tag-based proteomic profiling revealed potential therapeutic targets and mechanisms of liraglutide for the treatment of impaired glucose tolerance

ObjectiveBased on the tandem mass tag (TMT) technique, our study investigated the potential therapeutic targets of Liraglutide (LIRA) on streptozotocin (STZ) induced impaired glucose tolerance (IGT) in rats and discuss the biological mechanism of the drug against IGT.Methods10 rats were randomly sel...

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Bibliographic Details
Main Authors: Qiuyue Guo, Cong Han, Yunsheng Xu, Qingguang Chen, Xu Han, Sen Zhao, Jie Li, Hao Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Endocrinology
Subjects:
liraglutide (LIRA)
impaired glucose tolerance (IGT)
tandem mass tag (TMT) proteomics
protein targets
mechanism of action
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1031019/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.1031019/full

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