N6-methyladenosine methyltransferases: functions, regulation, and clinical potential

N6-methyladenosine methyltransferases: functions, regulation, and clinical potential

Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout the transcriptome with widespread functions in protein-coding and noncoding RNAs. It affects the fates of modified RNAs, including their stability, splicing, and/or translation, and thus plays important roles in pos...

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Bibliographic Details
Main Authors: Wei Huang, Tian-Qi Chen, Ke Fang, Zhan-Cheng Zeng, Hua Ye, Yue-Qin Chen
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Hematology & Oncology
Subjects:
m6A
m6A methyltransferase
Cancer
Therapy resistance
Drug discovery
Online Access:https://doi.org/10.1186/s13045-021-01129-8

Internet

https://doi.org/10.1186/s13045-021-01129-8

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