Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex

Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex

Abstract Background Mitochondria are the organelles responsible for energy metabolism and have a direct impact on neuronal function and survival. Mitochondrial abnormalities have been well characterized in Alzheimer Disease (AD). It is believed that mitochondrial fragmentation, due to impaired fissi...

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Main Authors: Sirui Jiang, Priya Nandy, Wenzhang Wang, Xiaopin Ma, Jeffrey Hsia, Chunyu Wang, Zhenlian Wang, Mengyue Niu, Sandra L. Siedlak, Sandy Torres, Hisashi Fujioka, Ying Xu, Hyoung-gon Lee, George Perry, Jun Liu, Xiongwei Zhu
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s13024-018-0238-8

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http://link.springer.com/article/10.1186/s13024-018-0238-8

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