NOTCH1-mutated chronic lymphocytic leukemia displays high endoplasmic reticulum stress response with druggable potential

NOTCH1-mutated chronic lymphocytic leukemia displays high endoplasmic reticulum stress response with druggable potential

IntroductionConstitutive activation of NOTCH1-wild-type (NT1-WT) signaling is associated with poor outcomes in chronic lymphocytic leukemia (CLL), and NOTCH1 mutation (c.7541_7542delCT), which potentiates NOTCH1 signaling, worsens the prognosis. However, the specific mechanisms of NOTCH1 deregulatio...

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Bibliographic Details
Main Authors: Estevão Carlos Silva Barcelos, Chiara Rompietti, Francesco Maria Adamo, Erica Dorillo, Filomena De Falco, Beatrice Del Papa, Stefano Baldoni, Manuel Nogarotto, Angela Esposito, Silvia Capoccia, Clelia Geraci, Daniele Sorcini, Arianna Stella, Roberta Arcaleni, Valentina Tini, Flávia Imbroisi Valle Errera, Emanuela Rosati, Paolo Sportoletti
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Oncology
Subjects:
chronic lymphocytic leukemia
NOTCH1 mutation
unfolded and integrated stress response
endoplasmic reticulum stress (ER stress)
curcumin
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1218989/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1218989/full

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