Ponatinib modulates the metabolic profile of obese mice by inhibiting adipose tissue macrophage inflammation

Ponatinib modulates the metabolic profile of obese mice by inhibiting adipose tissue macrophage inflammation

Obesity-induced metabolic syndrome is a rapidly growing conundrum, reaching epidemic proportions globally. Chronic inflammation in obese adipose tissue plays a key role in metabolic syndrome with a series of local and systemic effects such as inflammatory cell infiltration and inflammatory cytokine...

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Bibliographic Details
Main Authors: Zhuomiao Lin, Xiaochun Lin, Ying Lai, Congcong Han, Xinran Fan, Jie Tang, Shiqi Mo, Jiahui Su, Sijia Liang, Jinyan Shang, Xiaofei Lv, Siwan Guo, Ruiping Pang, Jiaguo Zhou, Tingting Zhang, Feiran Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
ponatinib
adipose tissue macrophages
obesity
metabolic dysfunction
tyrosine kinase inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1040999/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.1040999/full

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