Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex

Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex

The core CoREST complex (LHC) contains histone deacetylase HDAC1 and histone demethylase LSD1 held together by the scaffold protein CoREST. Here, we analyze the purified LHC with modified peptide and reconstituted semisynthetic mononucleosome substrates. LHC demethylase activity toward methyl-Lys4 i...

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Bibliographic Details
Main Authors: Mingxuan Wu, Dawn Hayward, Jay H Kalin, Yun Song, John WR Schwabe, Philip A Cole
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-06-01
Series:eLife
Subjects:
histone
epigenetics
enzymology
post-translational modification
semisynthesis
Online Access:https://elifesciences.org/articles/37231

Internet

https://elifesciences.org/articles/37231

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