Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance

Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance

ABSTRACTIn a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM−1, thereby triggering the exodus of immunosuppressive T cells from gut-asso...

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Bibliographic Details
Main Authors: Marine Fidelle, Ai-Ling Tian, Laurence Zitvogel, Guido Kroemer
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:OncoImmunology
Subjects:
Cancer immunotherapy
microbiota
immunosuppression
MAdCAM-1
bile acids
Enterocloster
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2023.2224672

Internet

https://www.tandfonline.com/doi/10.1080/2162402X.2023.2224672

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