Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance
In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM−1, thereby triggering the exodus of immunosuppressive T cells from gut-associated l...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | OncoImmunology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2023.2224672 |
| _version_ | 1826914920887746560 |
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| author | Marine Fidelle Ai-Ling Tian Laurence Zitvogel Guido Kroemer |
| author_facet | Marine Fidelle Ai-Ling Tian Laurence Zitvogel Guido Kroemer |
| author_sort | Marine Fidelle |
| collection | DOAJ |
| description | In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM−1, thereby triggering the exodus of immunosuppressive T cells from gut-associated lymphoid tissues toward tumors. |
| first_indexed | 2024-03-08T17:12:41Z |
| format | Article |
| id | doaj.art-42ad6abdc05048daa707a456a60607bf |
| institution | Directory Open Access Journal |
| issn | 2162-402X |
| language | English |
| last_indexed | 2025-02-17T11:52:08Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj.art-42ad6abdc05048daa707a456a60607bf2024-12-27T17:34:39ZengTaylor & Francis GroupOncoImmunology2162-402X2023-12-0112110.1080/2162402X.2023.2224672Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillanceMarine Fidelle0Ai-Ling Tian1Laurence Zitvogel2Guido Kroemer3Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, FranceIn a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM−1, thereby triggering the exodus of immunosuppressive T cells from gut-associated lymphoid tissues toward tumors.https://www.tandfonline.com/doi/10.1080/2162402X.2023.2224672Cancer immunotherapymicrobiotaimmunosuppressionMAdCAM-1bile acidsEnterocloster |
| spellingShingle | Marine Fidelle Ai-Ling Tian Laurence Zitvogel Guido Kroemer Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance OncoImmunology Cancer immunotherapy microbiota immunosuppression MAdCAM-1 bile acids Enterocloster |
| title | Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance |
| title_full | Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance |
| title_fullStr | Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance |
| title_full_unstemmed | Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance |
| title_short | Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance |
| title_sort | bile acids regulate madcam 1 expression to link the gut microbiota to cancer immunosurveillance |
| topic | Cancer immunotherapy microbiota immunosuppression MAdCAM-1 bile acids Enterocloster |
| url | https://www.tandfonline.com/doi/10.1080/2162402X.2023.2224672 |
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