An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition

An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition

The Main protease of SARS-CoV-2 is key for viral replication, but its maturation process is still not completely understood. Here, the authors not only reveal unique details from the first step of maturation, but also demonstrate how different classes of inhibitor can block this step.

Bibliographic Details
Main Authors: Gabriela Dias Noske, Yun Song, Rafaela Sachetto Fernandes, Rod Chalk, Haitem Elmassoudi, Lizbé Koekemoer, C. David Owen, Tarick J. El-Baba, Carol V. Robinson, The COVID Moonshot Consortium, Glaucius Oliva, Andre Schutzer Godoy
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37035-5

Internet

https://doi.org/10.1038/s41467-023-37035-5

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