Blockade of the deubiquitinating enzyme USP48 degrades oncogenic HMGA2 and inhibits colorectal cancer invasion and metastasis

Blockade of the deubiquitinating enzyme USP48 degrades oncogenic HMGA2 and inhibits colorectal cancer invasion and metastasis

HMGA2, a pivotal transcription factor, functions as a versatile regulator implicated in the progression of diverse aggressive malignancies. In this study, mass spectrometry was employed to identify ubiquitin-specific proteases that potentially interact with HMGA2, and USP48 was identified as a deubi...

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Bibliographic Details
Main Authors: Can Cheng, Hanhui Yao, Heng Li, Jingwen Liu, Zhengyi Liu, Yang Wu, Liang Zhu, Hejie Hu, Zhengdong Fang, Liang Wu
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Colorectal cancer
Invasion and metastasis
Post-translational modification
Ubiquitination
SUMOylation
USP48
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352400008X

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http://www.sciencedirect.com/science/article/pii/S221138352400008X

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