Loss of TTC17 promotes breast cancer metastasis through RAP1/CDC42 signaling and sensitizes it to rapamycin and paclitaxel

Loss of TTC17 promotes breast cancer metastasis through RAP1/CDC42 signaling and sensitizes it to rapamycin and paclitaxel

Abstract Background Breast cancer (BC) metastasis is the leading cause of poor prognosis and therapeutic failure. However, the mechanisms underlying cancer metastasis are far from clear. Methods We screened candidate genes related to metastasis through genome-wide CRISPR screening and high-throughpu...

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Bibliographic Details
Main Authors: Jingyao Zhang, Fengzhu Guo, Chunxiao Li, Yang Wang, Jinsong Wang, Fangzhou Sun, Yantong Zhou, Fei Ma, Bailin Zhang, Haili Qian
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Cell & Bioscience
Subjects:
TTC17
RAP1/CDC42
Metastasis
Breast cancer
Drug sensitivity
Online Access:https://doi.org/10.1186/s13578-023-01004-8

Internet

https://doi.org/10.1186/s13578-023-01004-8

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