Multiple aspects of lymphatic dysfunction in an ApoE−/− mouse model of hypercholesterolemia

Multiple aspects of lymphatic dysfunction in an ApoE−/− mouse model of hypercholesterolemia

Introduction: Rodent models of cardiovascular disease have uncovered various types of lymphatic vessel dysfunction that occur in association with atherosclerosis, type II diabetes and obesity. Previously, we presented in vivo evidence for impaired lymphatic drainage in apolipoprotein E null (ApoE−/−...

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Bibliographic Details
Main Authors: Michael J. Davis, Joshua P. Scallan, Jorge A. Castorena-Gonzalez, Hae Jin Kim, Lim Hwee Ying, Yeo Kim Pin, Veronique Angeli
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Physiology
Subjects:
lymphatic valve
permeability
contractile dysfunction
high fat diet
back-leak
pump limit
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.1098408/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.1098408/full

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