Efficacy of Flotetuzumab in Combination with Cytarabine in Patient-Derived Xenograft Models of Pediatric Acute Myeloid Leukemia

Efficacy of Flotetuzumab in Combination with Cytarabine in Patient-Derived Xenograft Models of Pediatric Acute Myeloid Leukemia

Children with acute myeloid leukemia (AML) have a poor prognosis despite the intensification of chemotherapy. Future efforts to improve outcomes should focus on more precise targeting of leukemia cells. CD123, or IL3RA, is expressed on the surface of nearly all pediatric AML samples and is a high-pr...

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Bibliographic Details
Main Authors: Sonali P. Barwe, Anne Kisielewski, Ezio Bonvini, John Muth, Jan Davidson-Moncada, Edward Anders Kolb, Anilkumar Gopalakrishnapillai
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Journal of Clinical Medicine
Subjects:
pediatric leukemia
acute myeloid leukemia
CD123
flotetuzumab
immunotherapy
patient-derived xenograft models
Online Access:https://www.mdpi.com/2077-0383/11/5/1333

Internet

https://www.mdpi.com/2077-0383/11/5/1333

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