Application of neural network-based image analysis to detect sister chromatid cohesion defects

Abstract Sister chromatid cohesion (SCC) is mediated by the cohesin complex and its regulatory proteins. To evaluate the involvement of a protein in cohesin regulation, preparations of metaphase chromosome spreads and classifications of chromosome shapes after depletion of the target protein are com...

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Bibliographic Details
Main Authors: Daiki Ikemoto, Tomoya Taniguchi, Kouji Hirota, Kiyoshi Nishikawa, Kan Okubo, Takuya Abe
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-28742-6