rs2013278 in the multiple immunological-trait susceptibility locus CD28 regulates the production of non-functional splicing isoforms

rs2013278 in the multiple immunological-trait susceptibility locus CD28 regulates the production of non-functional splicing isoforms

Abstract Background Ligation of CD28 with ligands such as CD80 or CD86 provides a critical second signal alongside antigen presentation by class II major histocompatibility complex expressed on antigen-presenting cells through the T cell antigen receptor for naïve T cell activation. A number of stud...

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Bibliographic Details
Main Authors: Yuki Hitomi, Yoshihiro Aiba, Kazuko Ueno, Nao Nishida, Yosuke Kawai, Minae Kawashima, Makoto Tsuiji, Chisato Iwabuchi, Sanami Takada, Noriko Miyake, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Human Genomics
Subjects:
Immunological-trait
Genome-wide association study (GWAS)
CD28
Primary functional variant
Alternative splicing
Linkage disequilibrium
Online Access:https://doi.org/10.1186/s40246-022-00419-7

Internet

https://doi.org/10.1186/s40246-022-00419-7

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