Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation

Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation

Abstract Background Autologous chondrocyte implantation (ACI) has a failure rate of approximately 20%, but it is yet to be fully understood why. Biomarkers are needed that can pre-operatively predict in which patients it is likely to fail, so that alternative or individualised therapies can be offer...

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Bibliographic Details
Main Authors: Charlotte H. Hulme, Emma L. Wilson, Heidi R. Fuller, Sally Roberts, James B. Richardson, Pete Gallacher, Mandy J. Peffers, Sally L. Shirran, Catherine H. Botting, Karina T. Wright
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Arthritis Research & Therapy
Subjects:
Autologous chondrocyte implantation (ACI)
iTRAQ proteomics
Label-free quantitation proteomics
Synovial fluid
Cartilage repair
Complement C1S subcomponent
Online Access:http://link.springer.com/article/10.1186/s13075-018-1573-4

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http://link.springer.com/article/10.1186/s13075-018-1573-4

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