Filgotinib Modulates Inflammation-Associated Peripheral Blood Protein Biomarkers in Adults with Active Rheumatoid Arthritis and Prior Inadequate Response to Methotrexate

Filgotinib Modulates Inflammation-Associated Peripheral Blood Protein Biomarkers in Adults with Active Rheumatoid Arthritis and Prior Inadequate Response to Methotrexate

Abstract Introduction Our aim was to evaluate protein biomarker changes related to the administration of filgotinib, a Janus kinase (JAK) 1 preferential inhibitor, in patients with moderately to severely active rheumatoid arthritis (RA) with inadequate response to methotrexate. Methods Plasma and se...

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Bibliographic Details
Main Authors: Yoshiya Tanaka, Peter C. Taylor, Emon Elboudwarej, Angie Hertz, Xiaorong Shao, Vladislav A. Malkov, Hironori Matsushima, Kahaku Emoto, Bryan Downie, Tsutomu Takeuchi
Format: Article
Language:English
Published: Adis, Springer Healthcare 2023-07-01
Series:Rheumatology and Therapy
Subjects:
Cytokines
Rheumatoid factor
Methotrexate
Biological therapy
Inflammation
Biomarker
Online Access:https://doi.org/10.1007/s40744-023-00583-9

Internet

https://doi.org/10.1007/s40744-023-00583-9

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